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Peptide record

TPDB16103

Antibacterial Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB16103
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FRKKLKKLFKKLSPVIPLLKLG
Physicochemical Analysis
C128H224N32O24
ANDCEQHMTWY
K
2595.39
11.93
8
0
10
+8
2.92
0.041
137.27
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
6
L
7
K
0
M
2
F
2
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 6 K: 7 M: 0 F: 2 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C128H224N32O24
2595.39
11.93
+8
2.92
0.041
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
<5% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species. | MBio | 2019
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
<5% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidin Peptides Restrict Bacterial Growth via Membrane Perturbation and Induction of Reactive Oxygen Species. | MBio | 2019