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Peptide record

TPDB16090

sKFGF (CN-7) Antibacterial Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16090
sKFGF (CN-7)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
AAKLLPDLLAAP-NH2
Physicochemical Analysis
C56H97N13O15
RNCEQGHIMFSTWYV
AL
1192.46
6.75
1
1
8
-0
0.20
0.983
163.33
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C56H97N13O15
1192.46
6.75
-0
0.20
0.983
Amidation
L
Amphipathic
Stapled
Free
N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293, HeLa Gram-Negative Strains (Escherichia Coli, Pseudomonas Aeruginosa) And Gram-Positive Strains (Staphylococcus Aureus, Enterococcus Faecalis).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Stapled L Amphipathic
Synthetic
Less active than linear R9
In vitro
CCCCHHHHTCCC
Additional Detail Fields 1 fields
CCCCHHHHTCCC