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Peptide record

TPDB16089

sWSSP (CN-6) Antibacterial Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB16089
sWSSP (CN-6)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
PLIKLRLDRGQF-NH2
Physicochemical Analysis
C67H114N20O16
ANCEHMSTWYV
L
1455.77
11.32
3
1
5
+2
1.76
-0.267
130.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
1
D
0
C
0
E
1
Q
1
G
0
H
1
I
3
L
1
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 3 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C67H114N20O16
1455.77
11.32
+2
1.76
-0.267
Amidation
L
Amphipathic
Stapled
Free
N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C/C(=C/NCC)/CCC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)O.C.C
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293, HeLa Gram-Negative Strains (Escherichia Coli, Pseudomonas Aeruginosa) And Gram-Positive Strains (Staphylococcus Aureus, Enterococcus Faecalis).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Stapled L Amphipathic
Synthetic
Less active than linear R9
In vitro
CCCSCCCSSSSCGGGHHHHHHHTTTC
Additional Detail Fields 1 fields
CCCSCCCSSSSCGGGHHHHHHHTTTC