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Peptide record

TPDB16088

sDRIM (CN-5) Antibacterial Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB16088
sDRIM (CN-5)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
QQRKRKIWSKLAPDGTTLVKLVAGIG-NH2
Physicochemical Analysis
C129H223N39O34
NCEHMFY
K
2864.43
11.63
6
1
10
+5
4.51
-0.331
105.00
Mammalian: 0.8 hour Yeast: 10 min E.coli: >10 hour
5500
192.01
5
Residue Composition
number
2
A
2
R
0
N
1
D
0
C
0
E
2
Q
3
G
0
H
2
I
3
L
4
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 2 L: 3 K: 4 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C129H223N39O34
2864.43
11.63
+5
4.51
-0.331
Amidation
L
Amphipathic
Stapled
Free
N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek293, HeLa Gram-Negative Strains (Escherichia Coli, Pseudomonas Aeruginosa) And Gram-Positive Strains (Staphylococcus Aureus, Enterococcus Faecalis).

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Stapled L Amphipathic
Synthetic
Less active than linear R9
In vitro
CCCGGGTSCCCCCCSCCCC
Additional Detail Fields 1 fields
CCCGGGTSCCCCCCSCCCC