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Peptide record

TPDB15929

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB15929
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia Antifungipept
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
GLSLLLSLGLKLL
Physicochemical Analysis
C64H118N14O16
ARNDCEQHIMFPTWYV
L
1339.72
10.10
1
0
8
+1
-3.21
1.854
240.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
8
L
1
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 8 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C64H118N14O16
1339.72
10.10
+1
-3.21
1.854
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus USA300 LAC

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against MRSA, S. aureus USA300 LAC (MIC 3.1 uM), S. aureus M838-17 , E. faecium V286-17 (MIC 3.1-6.2 uM) anti-VRE, not active against the
Evidence 2 Activity

Activity

MIC
Antibacterial
3.1-6.2 µM

Target

E. faecium V286-17

Source & Reference

dbAMP

Other

Active against MRSA, S. aureus USA300 LAC (MIC 3.1 uM), S. aureus M838-17 , E. faecium V286-17 (MIC 3.1-6.2 uM) anti-VRE, not active against the Gram- bacteria tested P.aeruginosa E411-17, K.pneumoniae
Evidence 3 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus USA300 LAC

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against MRSA, S. aureus USA300 LAC (MIC 3.1 uM), S. aureus M838-17 , E. faecium V286-17 (MIC 3.1-6.2 uM) anti-VRE, not active against the
Evidence 4 Activity

Activity

MIC
Antifungal
3.1-6.2 µM

Target

E. faecium V286-17

Source & Reference

dbAMP Antifungipept

Other

Active against MRSA, S. aureus USA300 LAC (MIC 3.1 uM), S. aureus M838-17 , E. faecium V286-17 (MIC 3.1-6.2 uM) anti-VRE, not active against the Gram- bacteria tested P.aeruginosa E411-17, K.pneumoniae
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens. | Proc Natl Acad Sci U S A | 2019