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Peptide record

TPDB15925

Antibacterial Antifungal Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB15925
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia Antifungipept CAFPdb
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SYERKINRHFKTLKKNLKKK
Physicochemical Analysis
C116H199N37O28
ADCQGMPWV
K
2560.09
11.26
10
1
5
+8
9.14
-1.895
58.50
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
58.20
5
Residue Composition
number
0
A
2
R
2
N
0
D
0
C
1
E
0
Q
0
G
1
H
1
I
2
L
7
K
0
M
1
F
0
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 7 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
20
C116H199N37O28
2560.09
11.26
+8
9.14
-1.895
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>640 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >640 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>640 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >640 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019
Evidence 3 Activity

Activity

25% Killing
Toxicity
640 µg/mL
Cytotoxic
25% Killing | 640 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Two optimized antimicrobial peptides with therapeutic potential for clinical antibiotic-resistant Staphylococcus aureus. | Eur J Med Chem | 2019