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Peptide record

TPDB15854

magainin 2-A-DesHDAP1 (M-A-D) Antibacterial Cell-penetrating Peptides standard
44 amino acids
Basic Information
3D PDB MODEL
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TPDB15854
magainin 2-A-DesHDAP1 (M-A-D)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 44-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
Sequence
GIGKWLHSAKKFGKAFVGEIMNSAARDNKKTRIWPRHLQLAVRN
Physicochemical Analysis
C227H366N72O56S1
CY
K
5031.91
12.02
12
2
18
+8
7.57
-0.598
77.73
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
218.60
7
Residue Composition
number
5
A
4
R
3
N
1
D
0
C
1
E
1
Q
4
G
2
H
3
I
3
L
6
K
1
M
2
F
1
P
2
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 4 N: 3 D: 1 C: 0 E: 1 Q: 1 G: 4 H: 2 I: 3 L: 3 K: 6 M: 1 F: 2 P: 1 S: 2 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
44
C227H366N72O56S1
5031.91
12.02
+8
7.57
-0.598
Free
L
Linear
Free
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli Spheroplasts

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
All hybrids showed significantly less translocation than either of the parent peptides, and no peptides showed translocation greater than the less translocating (more permeabilizing) parent peptide.
In vitro
CGGGTCSTHHHHTTHHHHTTTSEECCCTTSCCSSCCCCEEC
Additional Detail Fields 1 fields
CGGGTCSTHHHHTTHHHHTTTSEECCCTTSCCSSCCCCEEC