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Peptide record

TPDB15853

magainin 2-DesHDAP1 (M-D) Antibacterial Cell-penetrating Peptides standard
43 amino acids
Basic Information
3D PDB MODEL
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TPDB15853
magainin 2-DesHDAP1 (M-D)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 43-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
Sequence
GIGKWLHSAKKFGKAFVGEIMNSARDNKKTRIWPRHLQLAVRN
Physicochemical Analysis
C224H361N71O55S1
CY
K
4960.83
12.02
12
2
17
+8
7.74
-0.653
77.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
221.74
7
Residue Composition
number
4
A
4
R
3
N
1
D
0
C
1
E
1
Q
4
G
2
H
3
I
3
L
6
K
1
M
2
F
1
P
2
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 4 N: 3 D: 1 C: 0 E: 1 Q: 1 G: 4 H: 2 I: 3 L: 3 K: 6 M: 1 F: 2 P: 1 S: 2 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
43
C224H361N71O55S1
4960.83
12.02
+8
7.74
-0.653
Free
L
Linear
Free
N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli Spheroplasts

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
All hybrids showed significantly less translocation than either of the parent peptides, and no peptides showed translocation greater than the less translocating (more permeabilizing) parent peptide.
In vitro
CCCSSSSSSSSSSSCSSCSSSHHHHCSCGGGTTTTTTTTTTC
Additional Detail Fields 1 fields
CCCSSSSSSSSSSSCSSCSSSHHHHCSCGGGTTTTTTTTTTC