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Peptide record

TPDB15844

BF2-A-magainin (B-A-M) Antibacterial Cell-penetrating Peptides standard
46 amino acids
Basic Information
3D PDB MODEL
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TPDB15844
BF2-A-magainin (B-A-M)
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
dbAMP CPPsite3.0
standard
No
A 46-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from dbAMP and CPPsite3.0, with an available 3D structural model.
Sequence
TRSSRAGLQWPVGRVHRLLRKAGGIGKWLHSAKKFGKAFVGEIMNS
Physicochemical Analysis
C229H372N74O56S1
DCY
G
5089.99
12.59
12
1
18
+9
5.60
-0.380
78.48
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
11000
216.11
7
Residue Composition
number
4
A
5
R
1
N
0
D
0
C
1
E
1
Q
7
G
2
H
2
I
4
L
5
K
1
M
2
F
1
P
4
S
1
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 5 N: 1 D: 0 C: 0 E: 1 Q: 1 G: 7 H: 2 I: 2 L: 4 K: 5 M: 1 F: 2 P: 1 S: 4 T: 1 W: 2 Y: 0 V: 3
Chemical Descriptors
46
C229H372N74O56S1
5089.99
12.59
+9
5.60
-0.380
Free
L
Linear
Free
N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@H](O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O.CC.C.C.C.C.C
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli Spheroplasts

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Fusogenic
All hybrids showed significantly less translocation than either of the parent peptides, and no peptides showed translocation greater than the less translocating (more permeabilizing) parent peptide.
In vitro
CCCCSCCCCSSGGGSSSCTTSSCCCSSSGGGTTTTSCC
Additional Detail Fields 1 fields
CCCCSCCCCSSGGGSSSCTTSSCCCSSSGGGTTTTSCC