TPDB

3D PDB MODEL

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TPDB ID TPDB15826

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia

Sequence_Type

modified_plain

Has_Modification Yes

Description A 7-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.

Modification

Modified, details unspecified

Sequence

XXLXAXX

FASTA

>TPDB15826|Antibacterial;Anticancer;Toxicity|length=7
XXLXAXX

Formula C9H18N2O3

Absent Amino Acids RNDCEQGHIKMFPSTWYV

Common Amino Acids AL

Mass 202.25

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 2

Net Charge -0

Boman Index -0.73

Hydrophobicity 0.800

Aliphatic Index 70.00

Half Life

Mammalian: Yeast: E.coli:

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C9H18N2O3

Mass

202.25

PI

6.02

Net Charge

-0

Boman Index

-0.73

Hydrophobicity

0.800

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: HL-7702 (L02): IC50>50µM HUVEC: IC50>50µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Nat Commun. 2017 Aug 30 8(1):391.

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 24.6 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: HL-7702 (L02): IC50=24.6 µM HUVEC: IC50=18.6 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Nat Commun. 2017 Aug 30 8(1):391.

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 7.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: HL-7702 (L02): IC50=7.4 µM HUVEC: IC50=33.8 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Nat Commun. 2017 Aug 30 8(1):391.

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 14.9 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: HL-7702 (L02): IC50=14.9 µM HUVEC: IC50=18.6 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Nat Commun. 2017 Aug 30 8(1):391.