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Peptide record

TPDB15819

Antibacterial Antifungal Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB15819
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
KKWW
Physicochemical Analysis
C34H46N8O5
ARNDCEQGHILMFPSTYV
KW
646.79
10.60
2
0
2
+2
-1.72
-2.400
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
1700.71
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
4
C34H46N8O5
646.79
10.60
+2
-1.72
-2.400
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

15% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

45% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014