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Peptide record

TPDB15818

Antibacterial Antifungal Toxicity standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB15818
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 5-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
RIKWK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C35H59N11O6
ANDCEQGHLMFPSTYV
K
729.92
11.64
3
0
2
+3
3.75
-1.740
78.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
7.54
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
5 reviewed residue count
C35H59N11O6 sequence-only estimate (linear, free termini)
729.92 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
3.75 sequence-only estimate (linear, free termini)
-1.740 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

7% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

16% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
16% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 4 Activity

Activity

2% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 5 Activity

Activity

5% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 6 Activity

Activity

8% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014