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Peptide record

TPDB15816

Antibacterial Antifungal Hemolysis Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB15816
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KKIRWR
Physicochemical Analysis
C41H71N15O7
ANDCEQGHLMFPSTYV
RK
886.11
12.42
4
0
2
+4
1.44
-2.200
65.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
620.69
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
6
C41H71N15O7
886.11
12.42
+4
1.44
-2.200
Evidence Records 4 records
Evidence 1 Activity

Activity

35% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
35% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

80% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
80% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis