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Peptide record

TPDB15815

Antibacterial Antifungal Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB15815
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
KIKRWR
Physicochemical Analysis
C41H71N15O7
ANDCEQGHLMFPSTYV
RK
886.11
12.42
4
0
2
+4
1.44
-2.200
65.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
620.69
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
6
C41H71N15O7
886.11
12.42
+4
1.44
-2.200
Evidence Records 3 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

45% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
45% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014