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Peptide record

TPDB15811

Antibacterial Antifungal Hemolysis Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB15811
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RIKWWK
Physicochemical Analysis
C46H69N13O7
ANDCEQGHLMFPSTYV
KW
916.14
11.64
3
0
3
+3
-1.22
-1.600
65.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
1200.69
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
6
C46H69N13O7
916.14
11.64
+3
-1.22
-1.600
Evidence Records 7 records
Evidence 1 Activity

Activity

7% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
7% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

15% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

30% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
30% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 4 Activity

Activity

12% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 5 Activity

Activity

38% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
38% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 6 Activity

Activity

58% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
58% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 7 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis