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Peptide record

TPDB15808

Antibacterial Antifungal Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB15808
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KWWK
Physicochemical Analysis
C34H46N8O5
ARNDCEQGHILMFPSTYV
KW
646.79
10.60
2
0
2
+2
-1.72
-2.400
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
1700.71
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
4
C34H46N8O5
646.79
10.60
+2
-1.72
-2.400
Evidence Records 6 records
Evidence 1 Activity

Activity

55% Hemolysis
Toxicity
62.5-125 µg/mL
Hemolytic Cytotoxic
55% Hemolysis | 62.5-125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

65% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
65% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

16% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
16% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 5 Activity

Activity

80% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
80% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis