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Peptide record

TPDB15807

Antibacterial Toxicity modified_plain modified
2 amino acids
Basic Information
3D PDB MODEL
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TPDB15807
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
modified_plain
Yes
A 2-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XR
Physicochemical Analysis
C6H14N4O2
ANDCEQGHILKMFPSTWYV
R
174.20
11.05
1
0
0
+1
0.81
-2.250
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C6H14N4O2
174.20
11.05
+1
0.81
-2.250
Evidence Records 10 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
19 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 19 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo design and synthesis of ultra-short peptidomimetic antibiotics having dual antimicrobial and anti-inflammatory activities. | PLoS One | 2013
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Short self-assembling cationic antimicrobial peptide mimetics based on a 3,5-diaminobenzoic acid scaffold | Pept Sci | 2019
Evidence 3 Activity

Activity

8% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
8% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short self-assembling cationic antimicrobial peptide mimetics based on a 3,5-diaminobenzoic acid scaffold | Pept Sci | 2019
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short self-assembling cationic antimicrobial peptide mimetics based on a 3,5-diaminobenzoic acid scaffold | Pept Sci | 2019
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
305 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 305 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic antimicrobial peptidomimetics with therapeutic potential. | J Med Chem | 2008
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
245 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 245 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic antimicrobial peptidomimetics with therapeutic potential. | J Med Chem | 2008
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
60 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic antimicrobial peptidomimetics with therapeutic potential. | J Med Chem | 2008
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines | J Pept Sci | 2018
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
49 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 49 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of novel histidine-derived lipo-amino acids: applied in the synthesis of ultra-short antimicrobial peptidomimetics having potent antimicrobial activity, salt resistance and protease stability | Eur J Med Chem | 2013
Evidence 10 Activity

Activity

10% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. | Bioorg Med Chem Lett | 2013