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Peptide record

TPDB15789

Antibacterial Hemolysis Toxicity standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB15789
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia PD_Hemolysis
standard
No
A 8-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
RRRWWWWL
Physicochemical Analysis
C68H89N21O9
ANDCEQGHIKMFPSTYV
W
1344.59
12.70
3
0
5
+3
-5.53
-1.662
48.75
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1636.19
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
8
C68H89N21O9
1344.59
12.70
+3
-5.53
-1.662
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus M838-17

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus M838-17 (MIC 3.1 uM), P. aeruginosa E411-17 (MIC 6.25 uM), and K. pneumoniae E406-17 (MIC 6.25 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Pseudomonas aeruginosa E411-17

Source & Reference

dbAMP

Other

active against S. aureus M838-17 (MIC 3.1 uM), P. aeruginosa E411-17 (MIC 6.25 uM), and K. pneumoniae E406-17 (MIC 6.25 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Klebsiella pneumoniae E406-17

Source & Reference

dbAMP

Other

active against S. aureus M838-17 (MIC 3.1 uM), P. aeruginosa E411-17 (MIC 6.25 uM), and K. pneumoniae E406-17 (MIC 6.25 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
60 µM
Hemolytic Cytotoxic
50% Hemolysis | 60 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two distinct amphipathic peptide antibiotics with systemic efficacy. | Proc Natl Acad Sci U S A | 2020
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis