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Peptide record

TPDB15784

Antibacterial Anticancer Toxicity modified_plain modified
12 amino acids
Basic Information
3D PDB MODEL
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TPDB15784
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
modified_plain
Yes
A 12-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
IXIILPPLXPII
Physicochemical Analysis
C57H100N10O11
ARNDCEQGHKMFSTWYV
I
1101.48
6.02
0
0
7
-0
-1.32
2.108
227.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
5
I
2
L
0
K
0
M
0
F
3
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 5 L: 2 K: 0 M: 0 F: 0 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C57H100N10O11
1101.48
6.02
-0
-1.32
2.108
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
2 µM
Cytotoxic
IC50 | 2 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity. | J Nat Prod | 2015
Evidence 2 Activity

Activity

IC90
Toxicity
6 µM
Cytotoxic
IC90 | 6 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity. | J Nat Prod | 2015
Evidence 3 Activity

Activity

IC50
Toxicity
2 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: MRC-5:IC50=2µM IC90=6µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2015 Aug 28 78(8):1910-25.