Back to search

Peptide record

TPDB15778

Antibacterial Toxicity modified_plain modified
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15778
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
modified_plain
Yes
A 3-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
KXK
Physicochemical Analysis
C12H26N4O3
ARNDCEQGHILMFPSTWYV
K
274.36
10.60
2
0
0
+2
1.98
-2.600
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C12H26N4O3
274.36
10.60
+2
1.98
-2.600
Evidence Records 4 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 3 Activity

Activity

IC50
Toxicity
25.11±6.17 µg/mL
Cytotoxic
IC50 | 25.11±6.17 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Understanding the Role of Self-Assembly and Interaction with Biological Membranes of Short Cationic Lipopeptides in the Effective Design of New Antibiotics | Antibiotics (Basel) | 2022
Evidence 4 Activity

Activity

2% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 1000 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial benzodiazepine-based short cationic peptidomimetics. | J Pept Sci | 2015