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Peptide record

TPDB15777

Antibacterial Toxicity Tumor-homing Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB15777
Antibacterial Toxicity Tumor-homing Peptides
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia TumorHoPe2.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Toxicity, and Tumor-homing Peptides) peptide sequence curated from dbAMP, Peptipedia, and TumorHoPe2.0, with an available 3D structural model.
Sequence
KAAKKAAKAAKKAA
Physicochemical Analysis
C60H114N20O15
RNDCEQGHILMFPSTWYV
A
1355.69
11.21
6
0
8
+6
4.58
-0.643
57.14
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C60H114N20O15
1355.69
11.21
+6
4.58
-0.643
Evidence Records 3 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
>670 µM
Hemolytic Cytotoxic
<10% Hemolysis | >670 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996
Evidence 2 Activity

Activity

99% Killing
Toxicity
>525 µM
Cytotoxic
99% Killing | >525 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Additional Detail Fields 3 fields
Nanoworms(NWs), polyethylene glycol
Athymic nude mice, ApoE null mice
T7 phage / cyclic Cx7C and linear X7 peptide library