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Peptide record

TPDB15775

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB15775
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KLGKKLGKLGKKLG
Physicochemical Analysis
C68H130N20O15
ARNDCEQHIMFPSTWYV
K
1467.91
11.21
6
0
4
+6
3.74
-0.700
111.43
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
0
I
4
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 4 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C68H130N20O15
1467.91
11.21
+6
3.74
-0.700
Evidence Records 2 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
>780 µM
Hemolytic Cytotoxic
<10% Hemolysis | >780 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996
Evidence 2 Activity

Activity

0% Killing
Toxicity
400 µM
Cytotoxic
0% Killing | 400 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996