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Peptide record

TPDB15773

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB15773
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KLAKLAKKLAKLAKKLAKLAK
Physicochemical Analysis
C108H206N30O22
RNDCEQGHIMFPSTWYV
K
2277.01
11.41
9
0
12
+9
4.53
-0.071
140.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
9
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C108H206N30O22
2277.01
11.41
+9
4.53
-0.071
Evidence Records 2 records
Evidence 1 Activity

Activity

<10% Hemolysis
Toxicity
>520 µM
Hemolytic Cytotoxic
<10% Hemolysis | >520 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996
Evidence 2 Activity

Activity

99% Killing
Toxicity
9 µM
Cytotoxic
99% Killing | 9 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
De novo antimicrobial peptides with low mammalian cell toxicity. | J Med Chem | 1996