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Peptide record

TPDB15760

Antibacterial Antifungal Toxicity modified_plain modified
3 amino acids
Basic Information
3D PDB MODEL
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TPDB15760
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
modified_plain
Yes
A 3-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Modified, details unspecified
Sequence
XRR
Physicochemical Analysis
C12H26N8O3
ANDCEQGHILKMFPSTWYV
R
330.39
12.40
2
0
0
+2
1.62
-3.000
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C12H26N8O3
330.39
12.40
+2
1.62
-3.000
Evidence Records 15 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
39.72 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 39.72 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
116.28 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 116.28 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
70.11 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 70.11 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
37.54 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 37.54 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
207.62 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 207.62 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
42.04 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 42.04 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ultrashort Cationic Lipopeptides-Effect of N-Terminal Amino Acid and Fatty Acid Type on Antimicrobial Activity and Hemolysis | Molecules | 2020
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
>512 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity | Biomolecules | 2023
Evidence 9 Activity

Activity

IC50
Toxicity
32.12±6.26 µg/mL
Cytotoxic
IC50 | 32.12±6.26 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity | Biomolecules | 2023
Evidence 10 Activity

Activity

IC50
Toxicity
10.61±2.04 µg/mL
Cytotoxic
IC50 | 10.61±2.04 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity | Biomolecules | 2023
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
95.39±2.40 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 95.39±2.40 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity | Biomolecules | 2023
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
77.45±1.13 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 77.45±1.13 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity | Biomolecules | 2023
Evidence 13 Activity

Activity

IC50
Toxicity
10.12±0.66 µg/mL
Cytotoxic
IC50 | 10.12±0.66 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity | Biomolecules | 2023
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
110 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 110 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of novel histidine-derived lipo-amino acids: applied in the synthesis of ultra-short antimicrobial peptidomimetics having potent antimicrobial activity, salt resistance and protease stability | Eur J Med Chem | 2013
Evidence 15 Activity

Activity

10% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non hemolytic short peptidomimetics as a new class of potent and broad-spectrum antimicrobial agents. | Bioorg Med Chem Lett | 2013