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Peptide record

TPDB15730

Antibacterial Anticancer Antifungal Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB15730
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia Antifungipept CAFPdb
standard
No
A 29-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LKLSPKTKKTLKKVLKGAIKGAIAIASMA
Physicochemical Analysis
C138H255N37O34S1
RNDCEQHFWY
K
3008.83
11.36
8
0
14
+8
4.75
0.248
121.38
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
5
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
8
K
1
M
0
F
1
P
2
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 8 M: 1 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
29
C138H255N37O34S1
3008.83
11.36
+8
4.75
0.248
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
6.5±0.2 µM
Cytotoxic
IC50 | 6.5±0.2 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa. | Peptides | 2014
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
192±21 µM
Hemolytic Cytotoxic
50% Hemolysis | 192±21 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa. | Peptides | 2014
Evidence 3 Activity

Activity

LC50
Toxicity
192
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cells (RBC): LC50=192±21 µM | Cytotoxicity: HUVEC: LC50=6.5±0.2 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2014 Nov 61:114-21.