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Peptide record

TPDB15729

Antibacterial Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB15729
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFGSLLGKALRLWKKVL
Physicochemical Analysis
C91H152N24O19
NDCEQHIMPTY
L
1886.36
11.73
4
0
9
+4
-1.94
0.512
137.65
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
291.57
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
5
L
3
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 5 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
17
C91H152N24O19
1886.36
11.73
+4
-1.94
0.512
Evidence Records 5 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
2 10 72 72 %
[Ref.32590058]It showed significant toxicity at high concentrations. At the concentration of 16, 32, 64 and 128 µg/mL, CPF-13 displayed 2%, 10%, 72% and 72% hemolysis, respectively.

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Biochimie. 2020 Sep 176:1-11. doi: 10.1016/j.biochi.2020.06.003. Epub 2020 Jun 23.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 32 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
CPF-C1 analog with effective antimicrobial and antibiofilm activities against Staphylococcus aureus including MRSA | Biochimie | 2020
Evidence 3 Activity

Activity

75% Hemolysis
Toxicity
64-128 µg/mL
Hemolytic Cytotoxic
75% Hemolysis | 64-128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
CPF-C1 analog with effective antimicrobial and antibiofilm activities against Staphylococcus aureus including MRSA | Biochimie | 2020
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
72 %
Hemolytic
Hemolytic_activity: [Ref.32590058]It showed significant toxicity at high concentrations. At the concentration of 16, 32, 64 and 128 µg/mL, CPF-13 displayed 2%, 10%, 72% and 72% hemolysis, respectively.

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2020 Sep 176:1-11. doi: 10.1016/j.biochi.2020.06.003. Epub 2020 Jun 23.
Evidence 5 Hemolysis

Activity

2 10 72 72 %
% Hemolysis
[Ref.32590058]It showed significant toxicity at high concentrations. At the concentration of 16, 32, 64 and 128 µg/mL, CPF-13 displayed 2%, 10%, 72% and 72% hemolysis, respectively.
Hemolysis

Source & Reference

PD_Hemolysis
Biochimie. 2020 Sep 176:1-11. doi: 10.1016/j.biochi.2020.06.003. Epub 2020 Jun 23.
DRAMP4
PD_Hemolysis