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Peptide record

TPDB15710

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB15710
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 4-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KGGK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C16H32N6O5
ARNDCEQHILMFPSTWYV
GK
388.47
10.60
2
0
0
+2
2.30
-2.150
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4 reviewed residue count
C16H32N6O5 sequence-only estimate (linear, free termini)
388.47 sequence-only estimate (linear, free termini)
10.60 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
2.30 sequence-only estimate (linear, free termini)
-2.150 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

20% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 20 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Sustained Release of Antibacterial Lipopeptides from Biodegradable Polymers against Oral Pathogens. | PLoS One | 2016
Evidence 2 Activity

Activity

40% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
40% Hemolysis | 50 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Sustained Release of Antibacterial Lipopeptides from Biodegradable Polymers against Oral Pathogens. | PLoS One | 2016
Evidence 3 Activity

Activity

75% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
75% Hemolysis | 100 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Sustained Release of Antibacterial Lipopeptides from Biodegradable Polymers against Oral Pathogens. | PLoS One | 2016
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis