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Peptide record

TPDB15698

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15698
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FKQFYRRVRRYFQKF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C105H153N31O20
ANDCEGHILMPSTW
RF
2169.57
11.98
6
0
7
+6
4.41
-1.333
19.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
2980
1.37
4
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
0
I
0
L
2
K
0
M
4
F
0
P
0
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
15 reviewed residue count
C105H153N31O20 sequence-only estimate (linear, free termini)
2169.57 sequence-only estimate (linear, free termini)
11.98 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.41 sequence-only estimate (linear, free termini)
-1.333 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-perfectly Amphipathic α-Helical Structure Containing the XXYXX Sequence Improves the Biological Activity of Bovine αs2-Casein Antimicrobial Peptides. | J Agric Food Chem | 2020
Evidence 2 Activity

Activity

18.39% Killing
Toxicity
256 µM
Cytotoxic
18.39% Killing | 256 | µM | target cell: Human endothelial hybrid cells Ea.hy 926

Target

Human endothelial hybrid cells Ea.hy 926

Source & Reference

NA
DBAASP
Non-perfectly Amphipathic α-Helical Structure Containing the XXYXX Sequence Improves the Biological Activity of Bovine αs2-Casein Antimicrobial Peptides. | J Agric Food Chem | 2020