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Peptide record

TPDB15696

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15696
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FWRRYKKVKKYRRWF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C111H163N33O18
ANDCEQGHILMPST
RK
2247.73
12.01
8
0
7
+8
4.50
-1.880
19.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
13980
6.22
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
2
F
0
P
0
S
0
T
2
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 2 Y: 2 V: 1
Chemical Descriptors
15 reviewed residue count
C111H163N33O18 sequence-only estimate (linear, free termini)
2247.73 sequence-only estimate (linear, free termini)
12.01 sequence-only estimate (linear, free termini)
+8 sequence-only estimate (linear, free termini)
4.50 sequence-only estimate (linear, free termini)
-1.880 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Non-perfectly Amphipathic α-Helical Structure Containing the XXYXX Sequence Improves the Biological Activity of Bovine αs2-Casein Antimicrobial Peptides. | J Agric Food Chem
Evidence 2 Activity

Activity

13.99% Killing
Toxicity
256 µM
Cytotoxic
13.99% Killing | 256 | µM | target cell: Human endothelial hybrid cells Ea.hy 926

Target

Human endothelial hybrid cells Ea.hy 926

Source & Reference

NA
DBAASP
Non-perfectly Amphipathic α-Helical Structure Containing the XXYXX Sequence Improves the Biological Activity of Bovine αs2-Casein Antimicrobial Peptides. | J Agric Food Chem