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Peptide record

TPDB15681

Antibacterial Antifungal Hemolysis Toxicity standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB15681
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb PD_Hemolysis
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from dbAMP, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KKKKK
Physicochemical Analysis
C30H62N10O6
ARNDCEQGHILMFPSTWYV
K
658.89
11.12
5
0
0
+5
4.95
-3.900
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C30H62N10O6
658.89
11.12
+5
4.95
-3.900
Evidence Records 14 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
21.42 µg/mL
Cytotoxic
50% Cell death | 21.42 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>32 µg/mL
Cytotoxic
50% Cell death | >32 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
27.11 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 27.11 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 4 Activity

Activity

50% Cell death
Toxicity
17.59 µg/mL
Cytotoxic
50% Cell death | 17.59 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
8.31 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 8.31 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 6 Activity

Activity

50% Cell death
Toxicity
52.0 µg/mL
Cytotoxic
50% Cell death | 52.0 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 7 Activity

Activity

50% Cell death
Toxicity
28.3 µg/mL
Cytotoxic
50% Cell death | 28.3 | µg/mL | target cell: Human Colon Epithelial Cells HCEC

Target

Human Colon Epithelial Cells HCEC

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
22.3 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 22.3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 9 Activity

Activity

50% Cell death
Toxicity
35.9 µg/mL
Cytotoxic
50% Cell death | 35.9 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 10 Activity

Activity

50% Cell death
Toxicity
22.5 µg/mL
Cytotoxic
50% Cell death | 22.5 | µg/mL | target cell: Human Colon Epithelial Cells HCEC

Target

Human Colon Epithelial Cells HCEC

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 11 Activity

Activity

50% Cell death
Toxicity
20.8 µg/mL
Cytotoxic
50% Cell death | 20.8 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
4.9 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 4.9 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Poly-lysine peptidomimetics having potent antimicrobial activity without hemolytic activity | Amino Acids | 2014
Evidence 14 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis