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Peptide record

TPDB15667

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15667
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
RRGWARRLVFAFGRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C86H138N34O16
NDCEQHIKMPSTY
R
1904.26
13.10
6
0
7
+6
4.45
-0.767
58.67
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
2.89
0
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
0
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
15 reviewed residue count
C86H138N34O16 sequence-only estimate (linear, free termini)
1904.26 sequence-only estimate (linear, free termini)
13.10 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.45 sequence-only estimate (linear, free termini)
-0.767 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

3% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
3% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria. | Proc Natl Acad Sci U S A | 2020