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Peptide record

TPDB15664

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15664
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
RRGWARRLFFAYGRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C90H138N34O17
NDCEQHIKMPSTV
R
1968.30
12.70
6
0
7
+6
4.73
-1.133
39.33
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
3.55
1
Residue Composition
number
2
A
6
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
0
K
0
M
2
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
15 reviewed residue count
C90H138N34O17 sequence-only estimate (linear, free termini)
1968.30 sequence-only estimate (linear, free termini)
12.70 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
4.73 sequence-only estimate (linear, free termini)
-1.133 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
4% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic molecular evolution of host cell-compatible, antimicrobial peptides effective against drug-resistant, biofilm-forming bacteria. | Proc Natl Acad Sci U S A | 2020