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Peptide record

TPDB15650

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB15650
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia CancerPPD 2.0
standard
No
A 13-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CancerPPD 2.0, with an available 3D structural model.
Sequence
KRWHWWRRHWVVW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C101H132N32O14
ANDCEQGILMFPSTY
W
2018.37
12.71
6
0
7
+4
3.07
-1.531
44.62
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
13.62
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 2
Chemical Descriptors
13 reviewed residue count
C101H132N32O14 sequence-only estimate (linear, free termini)
2018.37 sequence-only estimate (linear, free termini)
12.71 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
3.07 sequence-only estimate (linear, free termini)
-1.531 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers. | Cell Mol Bioeng | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
76.9 µM
Cytotoxic
IC50 | 76.9 | µM | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers. | Cell Mol Bioeng | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HUVEC: IC50>100 µM NL20: IC50=76.9 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Cell Mol Bioeng. 2020 Jun 24 13(5):447-461.