TPDB

3D PDB MODEL

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TPDB ID TPDB15631

Peptide_Name

DPPIV inhibitor

Activity

Antibacterial Antidiabetic

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides

Database_Source

dbAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (Antibacterial and Antidiabetic) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.

Sequence

DPLV

FASTA

>TPDB15631|Antibacterial;Antidiabetic|length=4
DPLV

Formula C20H34N4O7

Absent Amino Acids ARNCEQGHIKMFSTWY

Common Amino Acids DLPV

Mass 442.51

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -1

Boman Index 1.19

Hydrophobicity 0.725

Aliphatic Index 170.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

1

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

4

Formula

C20H34N4O7

Mass

442.51

PI

3.10

Net Charge

-1

Boman Index

1.19

Hydrophobicity

0.725

Chemical_Mass

442.5052

Monoisotopic_Mass

442.2419

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antidiabetic

Activity Measurement 698.00 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source NA

Authors Theysgeur S., Cudennec B., Deracinois B., Perrin C., Guiller I., Lepoudère A., Flahaut C., Ravallec R.

Title

New bioactive peptides identified from a tilapia byproduct hydrolysate exerting effects on DPP-IV activity and intestinal hormones regulation after canine gastrointestinal simulated digestion. Molecules, 26, 136, 2021

Year 2021

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C20H34N4O7/c1-10(2)8-13(17(27)23-16(11(3)4)20(30)31)22-18(28)14-6-5-7-24(14)19(29)12(21)9-15(25)26/h10-14,16H,5-9,21H2,1-4H3,(H,22,28)(H,23,27)(H,25,26)(H,30,31)/t12-,13-,14-,16-/m0/s1 InChIKey=DKGUDUKGICPTBV-YXWQFLTLSA-N

Number_of_Residues

4