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Peptide record

TPDB15616

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15616
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FVDLKKIANILNSIF
Physicochemical Analysis
C83H135N19O21
RCEQGHMPTWY
I
1735.10
9.88
2
1
9
+1
-0.23
0.907
156.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
2
N
1
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
2
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 2 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C83H135N19O21
1735.10
9.88
+1
-0.23
0.907
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against S. aureus ATCC CRM 6538 (MIC 8 uM, pH 7), MRSA NCTC 12493 (MIC 16 uM), E. faecalis (MIC 32 uM), K.pneumoniae (MIC 256 uM), P.aeruginosa (MIC 128 uM), and E.coli (MIC 128 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
256 µM

Target

K.pneumoniae

Source & Reference

dbAMP

Other

eus ATCC CRM 6538 (MIC 8 uM, pH 7), MRSA NCTC 12493 (MIC 16 uM), E. faecalis (MIC 32 uM), K.pneumoniae (MIC 256 uM), P.aeruginosa (MIC 128 uM), and E.coli (MIC 128 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µM

Target

P.aeruginosa

Source & Reference

dbAMP

Other

, pH 7), MRSA NCTC 12493 (MIC 16 uM), E. faecalis (MIC 32 uM), K.pneumoniae (MIC 256 uM), P.aeruginosa (MIC 128 uM), and E.coli (MIC 128 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
128 µM

Target

E.coli

Source & Reference

dbAMP

Other

6 uM), E. faecalis (MIC 32 uM), K.pneumoniae (MIC 256 uM), P.aeruginosa (MIC 128 uM), and E.coli (MIC 128 uM).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
152.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 152.6 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
In Vitro & In Vivo Studies on Identifying and Designing Temporin-1CEh from the Skin Secretion of Rana chensinensis as the Optimised Antibacterial Prototype Drug | Pharmaceutics | 2022
Evidence 6 Activity

Activity

92.3% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
92.3% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
In Vitro & In Vivo Studies on Identifying and Designing Temporin-1CEh from the Skin Secretion of Rana chensinensis as the Optimised Antibacterial Prototype Drug | Pharmaceutics | 2022