Back to search

Peptide record

TPDB15576

Antibacterial Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15576
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
CKGAFKQTCKCY
Physicochemical Analysis
C59H94N16O16S3
RNDEHILMPSWV
CK
1379.67
9.11
3
0
3
+3
0.74
-0.458
8.33
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1615
117.06
6
Residue Composition
number
1
A
0
R
0
N
0
D
3
C
0
E
1
Q
1
G
0
H
0
I
0
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 3 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C59H94N16O16S3
1379.67
9.11
+3
0.74
-0.458
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram- E. coli ATCC 700928 (MBC 3.8 ug/ml), P. aeruginosa ATCC 10145 (MBC 3.8 ug/ml), Gram+ S. aureus U3300 (MBC 60 ug/ml), and B. subtilis 13933 (MBC 1.9 ug/ml).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against Gram- E. coli ATCC 700928 (MBC 3.8 ug/ml), P. aeruginosa ATCC 10145 (MBC 3.8 ug/ml), Gram+ S. aureus U3300 (MBC 60 ug/ml), and B. subtilis 13933 (MBC 1.9 ug/ml).
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Function of Short Amidated Peptide Fragments From the Tick-Derived OsDef2 Defensin. | J Pept Sci | 2019
Evidence 4 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 5 Activity

Activity

59.5±13.9% Cell death
Toxicity
256 µg/mL
Cytotoxic
59.5±13.9% Cell death | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 6 Activity

Activity

LC50
Toxicity
163.2 µg/mL
Cytotoxic
LC50 | 163.2 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024