TPDB

3D PDB MODEL

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TPDB ID TPDB15575

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.

Sequence

IRGYKGGYCK

FASTA

>TPDB15575|Antibacterial;Antifungal;Toxicity|length=10
IRGYKGGYCK

Formula C51H81N15O13S1

Absent Amino Acids ANDEQHLMFPSTWV

Common Amino Acids G

Mass 1144.36

PI 9.98

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +3

Boman Index 0.39

Hydrophobicity -0.910

Aliphatic Index 39.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 2980

Absorbance 280nm 260.41

Polar Residues 3

number

0

A

1

R

0

N

0

D

1

C

0

E

0

Q

3

G

0

H

1

I

0

L

2

K

0

M

0

F

0

P

0

S

0

T

0

W

2

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 0

Length

10

Formula

C51H81N15O13S1

Mass

1144.36

PI

9.98

Net Charge

+3

Boman Index

0.39

Hydrophobicity

-0.910

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against Gram- E. coli ATCC 700928 (MBC 3.8 ug/ml), P. aeruginosa ATCC 10145 (MBC 7.5 ug/ml), Gram+ S. aureus U3300 (MBC 30 ug/ml), and B. subtilis 13933 (MBC 7.5 ug/ml).

Evidence 2 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP CAFPdb

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against Gram- E. coli ATCC 700928 (MBC 3.8 ug/ml), P. aeruginosa ATCC 10145 (MBC 7.5 ug/ml), Gram+ S. aureus U3300 (MBC 30 ug/ml), and B. subtilis 13933 (MBC 7.5 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial Function of Short Amidated Peptide Fragments From the Tick-Derived OsDef2 Defensin. | J Pept Sci | 2019

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024

Evidence 5 Activity

Activity

Activity Endpoint 20% Cytotoxicity

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

20% Cytotoxicity | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024