TPDB

3D PDB MODEL

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TPDB ID TPDB15551

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.

Sequence

RRIRIRPPRLPRPRPRPYFMPRP

FASTA

>TPDB15551|Antibacterial;Anticancer;Toxicity|length=23
RRIRIRPPRLPRPRPRPYFMPRP

Formula C135H226N50O25S1

Absent Amino Acids ANDCEQGHKSTWV

Common Amino Acids R

Mass 2981.66

PI 12.94

Basic Residues 9

Acidic Residues 0

Hydrophobic Residues 6

Net Charge +9

Boman Index 7.41

Hydrophobicity -1.613

Aliphatic Index 50.87

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 49.97

Polar Residues 1

number

0

A

9

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

1

L

0

K

1

M

1

F

8

P

0

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 1 F: 1 P: 8 S: 0 T: 0 W: 0 Y: 1 V: 0

Length

23

Formula

C135H226N50O25S1

Mass

2981.66

PI

12.94

Net Charge

+9

Boman Index

7.41

Hydrophobicity

-1.613

Evidence 1 Activity

Activity

Activity Endpoint 3.1% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 2.6 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3.1% Hemolysis | 2.6 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. | BMC Biol | 2022

Evidence 2 Activity

Activity

Activity Endpoint 3.8% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10.4 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

3.8% Hemolysis | 10.4 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. | BMC Biol | 2022

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 755 µM

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 755 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. | BMC Biol | 2022

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

BMC Biol. 2022 May 16 20(1):114.