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Peptide record

TPDB15528

Antibacterial Antiparasitic Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB15528
Antibacterial Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia ToxinPred 3.0
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Antiparasitic, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FVKELWDKVKKMGSAAWSAAKGAFA
Physicochemical Analysis
C128H196N32O32S1
RNCQHIPTY
A
2727.22
10.38
5
2
14
+3
0.85
-0.008
62.80
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
403.34
2
Residue Composition
number
6
A
0
R
0
N
1
D
0
C
1
E
0
Q
2
G
0
H
0
I
1
L
5
K
1
M
2
F
0
P
2
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 5 M: 1 F: 2 P: 0 S: 2 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
25
C128H196N32O32S1
2727.22
10.38
+3
0.85
-0.008
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>250 µM
Hemolytic Cytotoxic
50% Hemolysis | >250 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities. | Biochem Pharmacol | 2021
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
48.2-56.9 µM
Cytotoxic
50% Cytotoxicity | 48.2-56.9 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities. | Biochem Pharmacol | 2021