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Peptide record

TPDB15511

Antibacterial Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB15511
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 38-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
GINLKRKGNIMKKVKNIFHKIANADPMIWGYVMLSESK
Physicochemical Analysis
C198H327N55O50S3
CQT
K
4374.29
10.69
9
2
17
+6
6.89
-0.316
92.37
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
159.80
7
Residue Composition
number
2
A
1
R
4
N
1
D
0
C
1
E
0
Q
3
G
1
H
5
I
2
L
7
K
3
M
1
F
1
P
2
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 4 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 1 I: 5 L: 2 K: 7 M: 3 F: 1 P: 1 S: 2 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
38
C198H327N55O50S3
4374.29
10.69
+6
6.89
-0.316
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Inhibited the growth of S. aureus (relative OD drop by 38%), B-subtilis (0%), E-coli (4%), and P. aeruginosa (13%) at 60 uM. Sequence provided by Dr. Jun Wang.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
41.31 µM
Hemolytic Cytotoxic
50% Hemolysis | 41.31 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of antimicrobial peptides from the human gut microbiome using deep learning. | Nat Biotechnol | 2022