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Peptide record

TPDB15508

Antibacterial Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB15508
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 36-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
AMTSRKRKFVWYVLSSSLKWLIKKAKKIGVQVCGFE
Physicochemical Analysis
C197H320N52O46S2
NDHP
K
4217.15
10.93
9
1
17
+8
2.10
-0.008
91.94
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
296.17
8
Residue Composition
number
2
A
2
R
0
N
0
D
1
C
1
E
1
Q
2
G
0
H
2
I
3
L
7
K
1
M
2
F
0
P
4
S
1
T
2
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 1 E: 1 Q: 1 G: 2 H: 0 I: 2 L: 3 K: 7 M: 1 F: 2 P: 0 S: 4 T: 1 W: 2 Y: 1 V: 4
Chemical Descriptors
36
C197H320N52O46S2
4217.15
10.93
+8
2.10
-0.008
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Inhibited the growth of S. aureus (relative OD drop by 43%), B-subtilis (0%), E. coli (46%), and P. aeruginosa (65%) at 60 uM. Sequence provided by Dr. Jun Wang.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
16.47 µM
Hemolytic Cytotoxic
50% Hemolysis | 16.47 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of antimicrobial peptides from the human gut microbiome using deep learning. | Nat Biotechnol | 2022