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Peptide record

TPDB15507

Antibacterial Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB15507
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 36-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
AMTLRKRKFAWYVLSSSLKWLIKKAKKIGVQVCGFE
Physicochemical Analysis
C198H322N52O45S2
NDHP
K
4215.18
10.93
9
1
18
+8
1.17
0.053
97.50
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
12490
296.31
7
Residue Composition
number
3
A
2
R
0
N
0
D
1
C
1
E
1
Q
2
G
0
H
2
I
4
L
7
K
1
M
2
F
0
P
3
S
1
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 0 C: 1 E: 1 Q: 1 G: 2 H: 0 I: 2 L: 4 K: 7 M: 1 F: 2 P: 0 S: 3 T: 1 W: 2 Y: 1 V: 3
Chemical Descriptors
36
C198H322N52O45S2
4215.18
10.93
+8
1.17
0.053
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Inhibited the growth of S. aureus (68%), B. subtilis (85%), E-coli (5%), and P. aeruginosa (62%) at 60 uM. Sequence provided by Dr. Jun Wang.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
2.67 µM
Hemolytic Cytotoxic
50% Hemolysis | 2.67 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of antimicrobial peptides from the human gut microbiome using deep learning. | Nat Biotechnol | 2022