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Peptide record

TPDB15506

Antibacterial Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB15506
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 35-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
KQKTLKKVWKLSEKVLIFASAFAKKAGAAEATLVL
Physicochemical Analysis
C180H303N45O45
RNDCHMPY
K
3817.66
10.74
8
2
19
+6
4.89
0.237
111.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
144.07
5
Residue Composition
number
7
A
0
R
0
N
0
D
0
C
2
E
1
Q
1
G
0
H
1
I
5
L
8
K
0
M
2
F
0
P
2
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 7 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 1 L: 5 K: 8 M: 0 F: 2 P: 0 S: 2 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
35
C180H303N45O45
3817.66
10.74
+6
4.89
0.237
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Inhibited the growth of S. aureus (55%), B. subtilis (46%), E. coli (61%), and P. aeruginosa (86%) at 60 uM. Sequence provided by Dr. Jun Wang.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
61.09 µM
Hemolytic Cytotoxic
50% Hemolysis | 61.09 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of antimicrobial peptides from the human gut microbiome using deep learning. | Nat Biotechnol | 2022