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Peptide record

TPDB15491

Antibacterial Anticancer Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB15491
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 19-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
RRWQWRPKRIVKLIKKWLR
Physicochemical Analysis
C126H208N42O21
ANDCEGHMFSTY
R
2647.31
13.01
9
0
8
+9
1.82
-1.321
97.37
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
623.28
1
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
4
K
0
M
0
F
1
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 4 M: 0 F: 0 P: 1 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
19
C126H208N42O21
2647.31
13.01
+9
1.82
-1.321
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Staphylococcus aureus KCTC 1621 or MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against Gram+ S. aureus KCTC 1621 or MRSA (MIC 4-8 uM), S. epidermidis KCTC 1917 (MIC 8 uM), B. subtilis KCTC 3068 (MIC 4 uM), vancomycin-resist
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus epidermidis KCTC 1917

Source & Reference

dbAMP

Other

active against Gram+ S. aureus KCTC 1621 or MRSA (MIC 4-8 uM), S. epidermidis KCTC 1917 (MIC 8 uM), B. subtilis KCTC 3068 (MIC 4 uM), vancomycin-resistant E. faecium (MIC 8 uM) anti-VRE, G
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. subtilis KCTC 3068

Source & Reference

dbAMP

Other

inst Gram+ S. aureus KCTC 1621 or MRSA (MIC 4-8 uM), S. epidermidis KCTC 1917 (MIC 8 uM), B. subtilis KCTC 3068 (MIC 4 uM), vancomycin-resistant E. faecium (MIC 8 uM) anti-VRE, Gram- E. coli KCTC 1682 (MIC 8 uM),
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

E. faecium

Source & Reference

dbAMP

Other

epidermidis KCTC 1917 (MIC 8 uM), B. subtilis KCTC 3068 (MIC 4 uM), vancomycin-resistant E. faecium (MIC 8 uM) anti-VRE, Gram- E. coli KCTC 1682 (MIC 8 uM), P. aeruginosa KCTC 1637 or multidrug-resist
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli KCTC 1682

Source & Reference

dbAMP

Other

subtilis KCTC 3068 (MIC 4 uM), vancomycin-resistant E. faecium (MIC 8 uM) anti-VRE, Gram- E. coli KCTC 1682 (MIC 8 uM), P. aeruginosa KCTC 1637 or multidrug-resistant strains (MIC 8 uM), and S. typhimurium KC
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa KCTC 1637 or multidrug-resistant strains

Source & Reference

dbAMP

Other

vancomycin-resistant E. faecium (MIC 8 uM) anti-VRE, Gram- E. coli KCTC 1682 (MIC 8 uM), P. aeruginosa KCTC 1637 or multidrug-resistant strains (MIC 8 uM), and S. typhimurium KCTC 1926 (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. typhimurium KCTC 1926

Source & Reference

dbAMP

Other

C 1682 (MIC 8 uM), P. aeruginosa KCTC 1637 or multidrug-resistant strains (MIC 8 uM), and S. typhimurium KCTC 1926 (MIC 4 uM).
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
10% Hemolysis | >128 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
A novel hybrid peptide composed of LfcinB6 and KR-12-a4 with enhanced antimicrobial, anti-inflammatory and anti-biofilm activities. | Sci Rep | 2022