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Peptide record

TPDB15486

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15486
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.
Sequence
FLALALGKEAIAKLK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C76H132N18O18
RNDCQHMPSTWYV
AL
1585.99
10.32
3
1
10
+2
-0.82
0.940
156.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
1
I
4
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15 reviewed residue count
C76H132N18O18 sequence-only estimate (linear, free termini)
1585.99 sequence-only estimate (linear, free termini)
10.32 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-0.82 sequence-only estimate (linear, free termini)
0.940 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

15% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
15% Hemolysis | 64 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Kassporin-KS1: A Novel Pentadecapeptide from the Skin Secretion of Kassina senegalensis: Studies on the Structure-Activity Relationships of Site-Specific "Glycine-Lysine" Motif Insertions | Antibiotics (Basel) | 2022
Evidence 2 Activity

Activity

22% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
22% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Kassporin-KS1: A Novel Pentadecapeptide from the Skin Secretion of Kassina senegalensis: Studies on the Structure-Activity Relationships of Site-Specific "Glycine-Lysine" Motif Insertions | Antibiotics (Basel) | 2022