Back to search

Peptide record

TPDB15484

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15484
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FLALALIQEAIAKLK
Physicochemical Analysis
C79H136N18O19
RNDCGHMPSTWYV
AL
1642.06
9.88
2
1
11
+1
-0.09
1.293
182.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
2
I
4
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 2 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C79H136N18O19
1642.06
9.88
+1
-0.09
1.293
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus NCTC 10788 64 uM), MRSA NCTC 12493 (MIC 64 uM), E. faecalis NCTC 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 4
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

E.coli NCTC 10418

Source & Reference

dbAMP

Other

ureus NCTC 10788 64 uM), MRSA NCTC 12493 (MIC 64 uM), E. faecalis NCTC 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa
Evidence 3 Activity

Activity

MIC
Antibacterial
>128 µM

Target

C.albicans NCTC 10231

Source & Reference

dbAMP

Other

TC 12493 (MIC 64 uM), E. faecalis NCTC 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa ATCC 27853 (MIC >128 uM). Mainly act
Evidence 4 Activity

Activity

MIC
Antibacterial
>128 µM

Target

K.pneumoniae ATCC 43816

Source & Reference

dbAMP

Other

C 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa ATCC 27853 (MIC >128 uM). Mainly active against Gram-positive pathogens. It
Evidence 5 Activity

Activity

MIC
Antibacterial
>128 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

(MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa ATCC 27853 (MIC >128 uM). Mainly active against Gram-positive pathogens. It showed minimum biofilm inhibitory conc
Evidence 6 Activity

Activity

<5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Kassporin-KS1: A Novel Pentadecapeptide from the Skin Secretion of Kassina senegalensis: Studies on the Structure-Activity Relationships of Site-Specific "Glycine-Lysine" Motif Insertions | Antibiotics (Basel) | 2022