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Peptide record

TPDB15484

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB15484
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia ToxinPred 3.0
standard
No
A 15-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
FLALALIQEAIAKLK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C79H136N18O19
RNDCGHMPSTWYV
AL
1642.06
9.88
2
1
11
+1
-1.09
1.293
182.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
1
Q
0
G
0
H
2
I
4
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 2 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15 reviewed residue count
C79H136N18O19 sequence-only estimate (linear, free termini)
1642.06 sequence-only estimate (linear, free termini)
9.88 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-1.09 sequence-only estimate (linear, free termini)
1.293 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus NCTC 10788 64 uM), MRSA NCTC 12493 (MIC 64 uM), E. faecalis NCTC 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 4
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

E.coli NCTC 10418

Source & Reference

dbAMP

Other

ureus NCTC 10788 64 uM), MRSA NCTC 12493 (MIC 64 uM), E. faecalis NCTC 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa
Evidence 3 Activity

Activity

MIC
Antibacterial
>128 µM

Target

C.albicans NCTC 10231

Source & Reference

dbAMP

Other

TC 12493 (MIC 64 uM), E. faecalis NCTC 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa ATCC 27853 (MIC >128 uM). Mainly act
Evidence 4 Activity

Activity

MIC
Antibacterial
>128 µM

Target

K.pneumoniae ATCC 43816

Source & Reference

dbAMP

Other

C 12697 (MIC 64 uM), E.coli NCTC 10418 (MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa ATCC 27853 (MIC >128 uM). Mainly active against Gram-positive pathogens. It
Evidence 5 Activity

Activity

MIC
Antibacterial
>128 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

(MIC 128 uM), C.albicans NCTC 10231 (MIC >128 uM), K.pneumoniae ATCC 43816 (MIC >128 uM), P.aeruginosa ATCC 27853 (MIC >128 uM). Mainly active against Gram-positive pathogens. It showed minimum biofilm inhibitory conc
Evidence 6 Activity

Activity

<5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Kassporin-KS1: A Novel Pentadecapeptide from the Skin Secretion of Kassina senegalensis: Studies on the Structure-Activity Relationships of Site-Specific "Glycine-Lysine" Motif Insertions | Antibiotics (Basel) | 2022