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Peptide record

TPDB15439

Antibacterial Antifungal Toxicity standard
52 amino acids
Basic Information
3D PDB MODEL
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TPDB15439
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 52-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
KSWWKKVFKPVERAGQRIRDASIKGLAVAQQGANVLSTIRGGPPVVAPPPQV
Physicochemical Analysis
C254H416N76O66
CHMY
V
5590.57
12.01
9
2
21
+7
10.05
-0.277
88.08
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
196.76
9
Residue Composition
number
6
A
4
R
1
N
1
D
0
C
1
E
4
Q
5
G
0
H
3
I
2
L
5
K
0
M
1
F
6
P
3
S
1
T
2
W
0
Y
7
V
Amino Acid Distribution
A: 6 R: 4 N: 1 D: 1 C: 0 E: 1 Q: 4 G: 5 H: 0 I: 3 L: 2 K: 5 M: 0 F: 1 P: 6 S: 3 T: 1 W: 2 Y: 0 V: 7
Chemical Descriptors
52
C254H416N76O66
5590.57
12.01
+7
10.05
-0.277
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
0.5-1.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.5-1.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>32 µM
Cytotoxic
IC50 | >32 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022