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Peptide record

TPDB15438

Antibacterial Antifungal Toxicity standard
49 amino acids
Basic Information
3D PDB MODEL
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TPDB15438
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 49-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
RSLWKKLFKPVERAGQRIRDATIKGIVIAQQGANVLATIRGGPAIPPGQ
Physicochemical Analysis
C237H400N74O62
CHMY
AGI
5278.24
12.25
9
2
20
+7
8.94
-0.202
101.63
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
104.20
8
Residue Composition
number
6
A
5
R
1
N
1
D
0
C
1
E
4
Q
6
G
0
H
6
I
3
L
4
K
0
M
1
F
4
P
1
S
2
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 6 R: 5 N: 1 D: 1 C: 0 E: 1 Q: 4 G: 6 H: 0 I: 6 L: 3 K: 4 M: 0 F: 1 P: 4 S: 1 T: 2 W: 1 Y: 0 V: 3
Chemical Descriptors
49
C237H400N74O62
5278.24
12.25
+7
8.94
-0.202
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.25-2.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-2.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-2.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
0.25-2.0 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-2.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-2.0 uM), P. aeruginos (MIC 1-2 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
19.45 µM
Cytotoxic
IC50 | 19.45 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022