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Peptide record

TPDB15437

Antibacterial Antifungal Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB15437
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 47-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
RWYKKIFKPVEKAVQRVRDGTLQALGVAQQAANVYATAQGAQQQRHA
Physicochemical Analysis
C234H377N75O65
CMS
A
5281.03
11.03
9
2
21
+6
9.76
-0.657
74.89
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
160.57
13
Residue Composition
number
9
A
4
R
1
N
1
D
0
C
1
E
8
Q
3
G
1
H
1
I
2
L
4
K
0
M
1
F
1
P
0
S
2
T
1
W
2
Y
5
V
Amino Acid Distribution
A: 9 R: 4 N: 1 D: 1 C: 0 E: 1 Q: 8 G: 3 H: 1 I: 1 L: 2 K: 4 M: 0 F: 1 P: 1 S: 0 T: 2 W: 1 Y: 2 V: 5
Chemical Descriptors
47
C234H377N75O65
5281.03
11.03
+6
9.76
-0.657
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.25-0.5 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 1-2 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 1-2 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
0.25-0.5 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 1-2 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
1-2 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 1-2 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>64 µM
Cytotoxic
IC50 | >64 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022
Evidence 6 Activity

Activity

<10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<10% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022
Evidence 7 Activity

Activity

<5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and antimicrobial activity of cecropin family in Hermetia illucens. | Dev Comp Immunol | 2023