Back to search

Peptide record

TPDB15436

Antibacterial Antifungal Toxicity standard
44 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB15436
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP Peptipedia CAFPdb
standard
No
A 44-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from dbAMP, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
SWWKKVFKPVEKLGQRVRDATIQGIGIAQQGANVLATVRGGPPQ
Physicochemical Analysis
C216H351N65O58
CHMY
G
4786.56
11.53
7
2
17
+5
7.57
-0.368
86.36
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11000
229.81
9
Residue Composition
number
4
A
3
R
1
N
1
D
0
C
1
E
5
Q
6
G
0
H
3
I
2
L
4
K
0
M
1
F
3
P
1
S
2
T
2
W
0
Y
5
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 5 G: 6 H: 0 I: 3 L: 2 K: 4 M: 0 F: 1 P: 3 S: 1 T: 2 W: 2 Y: 0 V: 5
Chemical Descriptors
44
C216H351N65O58
4786.56
11.53
+5
7.57
-0.368
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.25-0.5 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 0.5-1.0 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-1.0 µM

Target

P. aeruginos

Source & Reference

dbAMP

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 0.5-1.0 uM).
Evidence 3 Activity

Activity

MIC
Antifungal
0.25-0.5 µM

Target

Escherichia coli ATCC 8739

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 0.5-1.0 uM).
Evidence 4 Activity

Activity

MIC
Antifungal
0.5-1.0 µM

Target

P. aeruginos

Source & Reference

dbAMP CAFPdb

Other

Active against S-aureus ATCC 6538 (MIC >32-64 uM), E. coli ATCC 8739 (MIC 0.25-0.5 uM), P. aeruginos (MIC 0.5-1.0 uM).
Evidence 5 Activity

Activity

IC50
Toxicity
>32 µM
Cytotoxic
IC50 | >32 | µM | target cell: Human fibroblasts MRC-5 SV2

Target

Human fibroblasts MRC-5 SV2

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022
Evidence 6 Activity

Activity

<10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<10% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Vitro Evaluation of Antimicrobial Peptides from the Black Soldier Fly (Hermetia Illucens) against a Selection of Human Pathogens. | Microbiol Spectr | 2022